Catalytic promiscuity and the evolution of new enzymatic activities

1999/04/01 by Patrick O’Brien, Patrick J O'Brien, Daniel Herschlag · 10 citations
Biochemistry, Genetics and Molecular Biology · #Biochemical Acid Research Studies #Enzyme Catalysis and Immobilization #Photosynthetic Processes and Mechanisms

paper · pdf · doi:10.1016/s1074-5521(99)80033-7

crossref issued 1999/04/01 · crossref published 1999/04/01 · crossref published-print 1999/04/01 · openalex publication_date 1999/04/01 · crossref created 2002/07/25 · openalex created_date 2025/10/10 · crossref deposited 2025/10/21 · crossref indexed 2026/07/25 · openalex updated_date 2026/08/04

Citations

• A Proficient Enzyme
• Can homologous proteins evolve different enzymatic activities?
• ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION

Cited by

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• Conformational diversity and protein evolution – a 60-year-old hypothesis revisited
• The Latent Promiscuity of Newly Identified Microbial Lactonases Is Linked to a Recently Diverged Phosphotriesterase
• The 'evolvability' of promiscuous protein functions
• Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme
• Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
• Mutations Elevate an Underground Pathway to a Physiologically Relevant Protopathway
• Enzyme [wikipedia]