The 'evolvability' of promiscuous protein functions

2004/11/28 by Amir Aharoni, Leonid Gaidukov, Olga Khersonsky +5 · 5 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #ATP Synthase and ATPases Research #Biochemical Acid Research Studies #Pharmacogenetics and Drug Metabolism

paper · doi:10.1038/ng1482

crossref issued 2004/11/28 · crossref published 2004/11/28 · crossref published-online 2004/11/28 · openalex publication_date 2004/11/28 · crossref created 2004/11/28 · crossref published-print 2005/01/01 · crossref deposited 2023/05/18 · openalex created_date 2025/10/10 · crossref indexed 2026/07/16 · openalex updated_date 2026/07/29

Citations

• Catalytic promiscuity and the evolution of new enzymatic activities
• ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION
• Conformational diversity and protein evolution – a 60-year-old hypothesis revisited

Cited by

• How do new proteins arise?
• A structural model of latent evolutionary potentials underlying neutral networks in proteins
• Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme
• Intragenic compensation through the lens of deep mutational scanning
• Dan Tawfik [wikipedia]