Nuclear Speckles

2010/10/06 by David L. Spector, Angus I. Lamond · 1 citation
Biochemistry, Genetics and Molecular Biology · #RNA Research and Splicing #RNA modifications and cancer #Cancer-related molecular mechanisms research

paper · pdf · doi:10.1101/cshperspect.a000646

openalex publication_date 2010/10/06 · openalex created_date 2022/05/12 · openalex updated_date 2026/08/01

Abstract

Nuclear speckles, also known as interchromatin granule clusters, are nuclear domains enriched in pre-mRNA splicing factors, located in the interchromatin regions of the nucleoplasm of mammalian cells. When observed by immunofluorescence microscopy, they usually appear as 20-50 irregularly shaped structures that vary in size. Speckles are dynamic structures, and their constituents can exchange continuously with the nucleoplasm and other nuclear locations, including active transcription sites. Studies on the composition, structure, and dynamics of speckles have provided an important paradigm for understanding the functional organization of the nucleus and the dynamics of the gene expression machinery.

Citations

• Structure and Function in the Nucleus
• Nuclear speckles: a model for nuclear organelles
• Assembly of the Nuclear Transcription and Processing Machinery: Cajal Bodies (Coiled Bodies) and Transcriptosomes
• Paraspeckles

Cited by

• Cell nucleus [wikipedia]

Related

• Nuclear speckles enable processing of RNA from GC-rich isochores
• Major nuclear locales define nuclear genome organization and function beyond A and B compartments
• Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
• Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways
• Paraspeckles: nuclear bodies built on long noncoding RNA