Paraspeckles

2010/06/23 by Archa H. Fox, Angus I. Lamond · 4 citations
Engineering · Computer Science · #Advanced Optical Imaging Technologies #Optical Polarization and Ellipsometry #Computer Graphics and Visualization Techniques

paper · pdf · doi:10.1101/cshperspect.a000687

openalex publication_date 2010/06/23 · openalex created_date 2022/05/12 · openalex updated_date 2026/08/04

Abstract

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.

Citations

• Nuclear speckles: a model for nuclear organelles
• P54nrb Forms a Heterodimer with PSP1 That Localizes to Paraspeckles in an RNA-dependent Manner

Cited by

• Nuclear Speckles
• Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA
• AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells
• Cell nucleus [wikipedia]

Related

• Paraspeckles: nuclear bodies built on long noncoding RNA
• Nuclear paraspeckles function in mediating gene regulatory and apoptotic pathways
• Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu
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• Matrix stiffness-sensitive long noncoding RNA NEAT1 seeded paraspeckles in cancer cells