2009/08/31 by Charles S. Bond, Archa H. Fox · 1 citation
Biochemistry, Genetics and Molecular Biology · #Biology #Cancer-related molecular mechanisms research #Cell biology #Cell nucleus #Gene #Gene expression #Genetics #Long non-coding RNA #Non-coding RNA #Nucleus #RNA #RNA Research and Splicing #RNA regulation and disease #RNA splicing #RNA-binding protein #Ribonucleoprotein #Transcriptome
paper · pdf · doi:10.1083/jcb.200906113
openalex publication_date 2009/08/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) family. These proteins, together with the long nonprotein-coding RNA NEAT1 (MEN-epsilon/beta), associate to form paraspeckles and maintain their integrity. Given the large numbers of long noncoding transcripts currently being discovered through whole transcriptome analysis, paraspeckles may be a paradigm for a class of subnuclear bodies formed around long noncoding RNA.