Structure and Function in the Nucleus

1998/04/24 by Angus I. Lamond, William C. Earnshaw · 4 citations
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · Neuroscience · #Biology #Cell biology #Cell nucleus #Computational biology #Engineering #Function (biology) #Neurogenetic and Muscular Disorders Research #Neuroscience #Nuclear Structure and Function #Nuclear transport #Nucleus #RNA Research and Splicing #Substructure

paper · doi:10.1126/science.280.5363.547

openalex publication_date 1998/04/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.

Citations

• Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories
• Active and inactive genes localize preferentially in the periphery of chromosome territories.

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• Cell nucleus [wikipedia]