The redox-A 3 reaction

2014/01/01 by Daniel Seidel · 1 citation
Chemistry · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Synthesis and Catalytic Reactions

paper · doi:10.1039/c4qo00022f

openalex publication_date 2014/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

This highlight details the recent emergence of a new type of A ³ reaction that features a redox-neutral C–H functionalization step.

Citations

• A walk around the A3-coupling
• Enantioselective Double Manipulation of Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Copper(I) Catalysis
• Redox‐Neutral Copper(II) Carboxylate Catalyzed α‐Alkynylation of Amines
• Aldehyde- and Ketone-Induced Tandem Decarboxylation-Coupling (Csp3−Csp) of Natural α-Amino Acids and Alkynes
• Nontraditional Reactions of Azomethine Ylides: Decarboxylative Three-Component Couplings of α-Amino Acids
• CuI-Catalyzed C1-Alkynylation of Tetrahydroisoquinolines (THIQs) by A3 Reaction with Tunable Iminium Ions
• The Copper‐Catalyzed Decarboxylative Coupling of the sp3‐Hybridized Carbon Atoms of α‐Amino Acids

Cited by

• A3 coupling reaction [wikipedia]

Related

• Evolution of C–H Bond Functionalization from Methane to Methodology
• Recent advances in C(sp 3 )–H functionalization via molecular electrocatalysis
• Triple C–F bond functionalization via an orderly elimination–oxidation–substitution relay reaction
• Beyond HAT: harnessing TBADT for photocatalyzed Giese-type C(sp 3 )–C(sp 3 ) bond formation through reductive decarboxylation
• Site-selective α-C(sp 3 )–H bond functionalization of amines/amides via 1,2-hydrogen atom transfer