Triple C–F bond functionalization via an orderly elimination–oxidation–substitution relay reaction

2025/01/01 by Xiongda Xie, Haoran Xu, Lixin Qian +6 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic C–H Functionalization Methods #Cyclopropane Reaction Mechanisms #Fluorine in Organic Chemistry

paper · doi:10.1039/d5qo00864f

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

A comovement group strategy is presented, which enables an orderly triple C–F bond functionalization process, providing practical access to α-ketoamides from readily available reagents by using water and oxygen in air as oxygen atom sources.

Citations

• Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
• Recent progress on selective deconstructive modes of halodifluoromethyl and trifluoromethyl-containing reagents
• A LORENTZ-COVARIANT LOW EQUATION

Discussions

• 🔥 The authors introduced a novel #comovement group (CG) strategy where the cleavage of each C–F bond occurs through different reactions initiated by distinct CGs, enabling an orderly and diversified [bsky, 0 points, 0 comments]

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