Site-selective α-C(sp 3 )–H bond functionalization of amines/amides via 1,2-hydrogen atom transfer

2026/01/01 by Dong Zou, Jiaqi Yao · 1 voice
Chemistry · #Catalytic C–H Functionalization Methods #Radical Photochemical Reactions #Advanced Synthetic Organic Chemistry

paper · doi:10.1039/d6qo00382f

openalex publication_date 2026/01/01 · openalex created_date 2026/04/28 · openalex updated_date 2026/06/17

Abstract

Nitrogen-centered radical-mediated 1,2-hydrogen atom transfer (1,2-HAT) serves as a robust strategy for the site-selective α-C(sp 3 )–H functionalization of amines and amides.

Citations

• Contribution of Organofluorine Compounds to Pharmaceuticals
• Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds
• Visible light photoredox-catalysed remote C–H functionalisation enabled by 1,5-hydrogen atom transfer (1,5-HAT)
• Late-stage difluoromethylation: concepts, developments and perspective
• Photoredox-enabled C(sp 3 )–H functionalization of amines through iminium ions, radicals, and carbanions

Discussions

• 🔔 Hot article by Jiaqi Yao 𝘦𝘵 𝘢𝘭. Site-selective α-C(sp³)–H bond functionalization of amines/amides via 1,2-hydrogen atom transfer 🔗 doi.org/10.1039/D6QO... #OrganicChemistry #HAT #Catalysis [bsky, 0 points, 0 comments]

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