Synthesis of α-Amino Acids by ConPET-Mediated CO 2 Fixation into Amides

2025/10/17 by Kimberly Benedetti Vega, Alejandro Heredero Sánchez, Tanumoy Mandal +6 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · #Advanced Synthetic Organic Chemistry #Asymmetric Hydrogenation and Catalysis #Chemical Synthesis and Analysis

paper · pdf · doi:10.1021/acscatal.5c04666

openalex created_date 2025/10/17 · openalex publication_date 2025/10/17 · openalex updated_date 2026/07/30

Abstract

High Resolution Image Download MS PowerPoint Slide Herein, we report a photocatalytic method for the selective functionalization of α-C(sp 3 )-H bonds adjacent to the nitrogen atom in amides. By harnessing a synergistic combination of hydrogen atom transfer (HAT), consecutive photoinduced electron transfer (ConPET), and reductive radical-polar crossover, we efficiently incorporated high-value electrophiles, including CO 2, 13 CO 2, and deuterium, at the α- N position. The transformation proceeds in moderate to high yields across a diverse range of amides, representing a significant advancement in both isotopically labeled α-amino acid synthesis and amide deuteration.

Citations

• Applications of Halogen-Atom Transfer (XAT) for the Generation of Carbon Radicals in Synthetic Photochemistry and Photocatalysis
• Reactivity of Superbasic Carbanions Generated via Reductive Radical‐Polar Crossover in the Context of Photoredox Catalysis

Discussions

• We thank B. List and L. Alama for highlighting our collaboration pubs.acs.org/doi/10.1021/... in Synfacts! #ChemSky #photocatalysis Synthesis of α-Amino Acids via ConPET-Driven Amide Activation doi [bsky, 3 points, 0 comments]

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