Beyond HAT: harnessing TBADT for photocatalyzed Giese-type C(sp 3 )–C(sp 3 ) bond formation through reductive decarboxylation

2025/01/01 by Matteo Leone, Dalila Arnaldi, Maurizio Fagnoni · 1 voice
Chemistry · #Catalytic C–H Functionalization Methods #Oxidative Organic Chemistry Reactions #Radical Photochemical Reactions

paper · pdf · doi:10.1039/d5qo00399g

openalex publication_date 2025/01/01 · openalex created_date 2025/05/04 · openalex updated_date 2026/07/08

Abstract

Our study reports a novel application of TBADT as a valid reductant, overcoming the intrinsic limitations of hydrogen atom transfer. Our methodology was applied for the generation of unnatural α-amino acids.

Citations

• Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
• Generation of Alkyl Radicals: From the Tyranny of Tin to the Photon Democracy
• Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C–H Bonds Elaboration
• Photocatalytic Late-Stage C–H Functionalization

Discussions

• 📢Don't miss the #OpenAccess research by Maurizio Fagnoni et al. at University of Pavia 👉Beyond HAT: harnessing TBADT for photocatalyzed Giese-type C(sp3)–C(sp3) bond formation through reductive #de [bsky, 0 points, 0 comments]