Silencing NCAPD3 Inhibits Tumor Growth and Metastasis in Hepatocellular Carcinoma by Suppressing PI3K-AKT Signalling Pathway

2025/03/03 by Jun Lv, Fu-yuan Gan, Minghao Li +2 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · #Heat shock proteins research #Hippo pathway signaling and YAP/TAZ #Protein Kinase Regulation and GTPase Signaling

paper · doi:10.1007/s11596-025-00026-2

crossref issued 2025/03/03 · crossref published 2025/03/03 · crossref published-online 2025/03/03 · openalex publication_date 2025/03/03 · crossref created 2025/03/03 · crossref published-print 2025/04/01 · crossref deposited 2025/05/05 · openalex created_date 2025/10/10 · crossref indexed 2026/03/18 · openalex updated_date 2026/07/31

Citations

• Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
• Targeting PI3K/Akt signal transduction for cancer therapy

Cited by

• MRPL42 Knockdown Suppresses the Malignant Functions of Hepatocellular Carcinoma by Regulating Oxidative Phosphorylation
• UXS1 Knockdown Suppresses Cell Proliferation and Invasion in Hepatocellular Carcinoma by Inducing Ferroptosis via SLC7A11/GPX4 Pathway

Discussions

• Elevated NCAPD3 expression strongly correlates with #HepatocellularCarcinoma #Metastasis, while its inhibition mitigates HCC cell growth and metastatic potential by suppressing the PI3K–AKT signalling [bsky, 1 points, 0 comments]