Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021/02/04 by Hyuna Sung, Jacques Ferlay, Adalberto M. Filho +5 · 355 citations
Medicine · #Colorectal Cancer Screening and Detection #Global Cancer Incidence and Screening #Multiple and Secondary Primary Cancers
paper · pdf · doi:10.3322/caac.21660
openalex publication_date 2021/02/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract
This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
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- GLAM: Geometry-Guided Local Alignment for Multi-View VLP in Mammography
- Comparison of False-Positive Versus True-Positive Findings on Contrast-Enhanced Digital Mammography
- Live(r) Die: Predicting Survival in Colorectal Liver Metastasis
- Evolution, the mother of age-related diseases
- Integrative Prognostic Modeling of Breast Cancer Survival with Gene Expression and Clinical Data
- A Multi-Modal Deep Learning Framework for Colorectal Pathology Diagnosis: Integrating Histological and Colonoscopy Data in a Pilot Study
- Interpretable Deep Transfer Learning for Breast Ultrasound Cancer Detection: A Multi-Dataset Study
- New approaches and procedures for cancer treatment: Current perspectives
- Inflammatory burden as a prognostic biomarker for cancer
- Achieving chronic hepatitis B functional cure: Factors and potential mechanisms
- Application of Small Cell Lung Cancer Molecular Subtyping Markers to Small Cell Neuroendocrine Carcinoma of the Cervix
- Evaluating safety and quality of robotic-assisted gastric cancer surgery: meta-analysis and meta-regression
- Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
- DeepStationing: Thoracic Lymph Node Station Parsing in CT Scans using Anatomical Context Encoding and Key Organ Auto-Search
- Polymeric Nanoparticles for Drug Delivery
- Uncertainty-Aware Learning Policy for Reliable Pulmonary Nodule Detection on Chest X-Ray
- Precision Oncology: Targeting Genomic Alterations and Cancer Signaling with Integrative Multi-Omics, Deep Learning and Network Biology in Medical Oncology
- Characteristics of auto-quantified tumor-infiltrating lymphocytes and the prognostic value in adenocarcinoma of the esophagogastric junction, gastric adenocarcinoma, and esophageal squamous cell carcinoma
- Identification of susceptibility loci using a novel murine model for triple-negative breast cancer
- A switch-on chemo-photothermal nanotherapy impairs glioblastoma
- Educational inequalities in gastric cancer incidence and mortality, 1996–2015: a population-based study in Quito-Ecuador
- Landscape of Somatic and Age‐Related Pathogenic Structural Variations in Hepatocellular Carcinoma Revealed by Long‐Read Sequencing
- LungSurg: A Generative AI System for Segmentation and Phase Classification in Thoracoscopic Lobectomy
- SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer
- The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma
- Synthesis, Anticancer Evaluation, and Molecular Docking of Triazolylmethyl‐Dihydroquinazolinyl Benzoate Derivatives as Potential PARP‐1 Inhibitors
- Identification of immunotherapy-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognostic signature in gastric carcinoma
- The incidence of avid lesions in head and neck cancer patients undergoing positron emission tomography-computed tomography scanning
- Advanced Deep Learning Techniques for Accurate Lung Cancer Detection and Classification
- Scaling Artificial Intelligence for Prostate Cancer Detection on MRI towards Organized Screening and Primary Diagnosis in a Global, Multiethnic Population (Study Protocol)
- Demographic Profile and Etiology of Hepatocellular Carcinoma in Zaria, Northern Nigeria
- The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC
- Subtyping Breast Lesions via Generative Augmentation based Long-tailed Recognition in Ultrasound
- Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. [europepmc]
- Extracellular matrix and its therapeutic potential for cancer treatment. [europepmc]
- Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer. [europepmc]
- Global colorectal cancer burden in 2020 and projections to 2040. [europepmc]
- Reactive oxygen species in cancer: Current findings and future directions. [europepmc]
- Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020. [europepmc]
- Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020. [europepmc]
- Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. [europepmc]
- Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer. [europepmc]
- Understanding breast cancer as a global health concern. [europepmc]
- Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. [europepmc]
- Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer. [europepmc]
- Cancer statistics in China and United States, 2022: profiles, trends, and determinants. [europepmc]
- Antibody drug conjugate: the "biological missile" for targeted cancer therapy. [europepmc]
- Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040. [europepmc]
- Recent advances in therapeutic strategies for triple-negative breast cancer. [europepmc]
- Global burden of primary liver cancer in 2020 and predictions to 2040. [europepmc]
- The sirtuin family in health and disease. [europepmc]
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments. [europepmc]
- Helicobacter pylori infection. [europepmc]
- Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. [europepmc]
- AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. [europepmc]
- 2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review. [europepmc]
- Gastric cancer treatment: recent progress and future perspectives. [europepmc]
- High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis. [europepmc]
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