Global cancer statistics, 2012
2015/02/04 by Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel +3 · 52 citations
Medicine · #Colorectal Cancer Screening and Detection #Global Cancer Incidence and Screening #Esophageal Cancer Research and Treatment
paper · pdf · doi:10.3322/caac.21262
Abstract
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
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- miR-30d-5p inhibits proliferation, invasion and migration of breast cancer cells by targeting SERPINE1 and promoting fatty acid β-oxidation
- Patient Perspectives on Telemonitoring during Colorectal Cancer Surgery Prehabilitation
- Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments
- Incidence, Risk Factors, and Prognosis of Patients with Hepatocellular Carcinoma and Brain Metastases
- Beyond endocrine resistance: estrogen receptor (ESR1) activating mutations mediate chemotherapy resistance through the JNK/c-Jun MDR1 pathway in breast cancer
- The effect of organized breast cancer screening on mammography use: Evidence from France
- MicroRNA‐1 overexpression increases chemosensitivity of non‐small cell lung cancer cells by inhibiting autophagy related 3‐mediated autophagy
- Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society. [europepmc]
- Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. [europepmc]
- Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. [europepmc]
- Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis. [europepmc]
- Integrated genomic characterization of oesophageal carcinoma. [europepmc]
- Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma. [europepmc]
- Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions. [europepmc]
- Renal cell carcinoma. [europepmc]
- Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. [europepmc]
- Oesophageal cancer. [europepmc]
- Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors. [europepmc]
- Direct detection of early-stage cancers using circulating tumor DNA. [europepmc]
- Deep Learning-Based Multi-Omics Integration Robustly Predicts Survival in Liver Cancer. [europepmc]
- Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. [europepmc]
- Cancer incidence and mortality in China, 2014. [europepmc]
- Prevalence of Antibiotic Resistance in Helicobacter pylori: A Systematic Review and Meta-analysis in World Health Organization Regions. [europepmc]
- Molecular therapies and precision medicine for hepatocellular carcinoma. [europepmc]
- Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. [europepmc]
- Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. [europepmc]
- Global Epidemiology of Lung Cancer. [europepmc]
- Tumor Microenvironment. [europepmc]
- Triple-negative breast cancer molecular subtyping and treatment progress. [europepmc]
- The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects. [europepmc]
- The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. [europepmc]
- Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition). [europepmc]
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