2020/02/28 by Timothée Constantin, Margherita Zanini, Alessio Regni +3 · 9 citations
Chemistry · #Catalytic C–H Functionalization Methods #Radical Photochemical Reactions #Sulfur-Based Synthesis Techniques
paper · doi:10.1126/science.aba2419
openalex publication_date 2020/02/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Amines as a gateway to alkyl radicals In recent years, photoredox catalysis driven by blue light has often been used to oxidize carbon centers adjacent to nitrogen. Constantin et al. now show that these aminoalkyl radicals can, in turn, conveniently strip iodine atoms from a variety of alkyl carbons. The new alkyl radicals that result readily undergo deuteration and couplings such as alkylation, allylation, and olefination. The upshot is that simple amines can replace more hazardous conventional reagents such as trialkyltin compounds in the homolytic activation and functionalization of halocarbons. Science , this issue p. 1021