Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis

2024/11/26 by Lauren E. Ehehalt, Omar M. Beleh, Isabella C. Priest +9 · 1 voice · 3 citations
Chemistry · #Asymmetric Synthesis and Catalysis #Catalytic Cross-Coupling Reactions #Chemical synthesis and alkaloids

paper · pdf · doi:10.1021/acs.chemrev.4c00524

openalex publication_date 2024/11/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

)-C(sp) bond formation. Additional chapters include alkene difunctionalization, alkyne difunctionalization, and formation of carbon-heteroatom bonds. Each chapter is generally organized with an initial summary of mechanisms followed by detailed figures and notes on methodological developments and ending with application notes in synthesis. While XEC is becoming an increasingly utilized approach in synthesis, its early stage of development means that optimal catalysts, ligands, additives, and reductants are still in flux. This review has collected data on these and various other aspects of the reactions to capture the state of the field. Finally, the data collected on the papers in this review is offered as Supporting Information for readers.

Citations

• Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides
• Mechanisms of Nickel-Catalyzed Coupling Reactions and Applications in Alkene Functionalization
• Enantioselective Three-Component Fluoroalkylarylation of Unactivated Olefins through Nickel-Catalyzed Cross-Electrophile Coupling
• Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions
• Nickel-Catalyzed Dicarbofunctionalization of Alkenes
• Cross-Electrophile Couplings of Activated and Sterically Hindered Halides and Alcohol Derivatives
• Eight-Step Asymmetric Synthesis of (–)-Berkelic Acid

Cited by

• Palladium-Catalyzed <i>ortho-</i> Alkylation of Bromoarenes Enabled by Imidazole-Olefin Ligands
• Reactivity Studies of Bipyridine-Ligated Nickel(I) and Nickel(0) Complexes Inform the Mechanism in Modern Cross-Coupling Reactions
• Cyclometalated Ni(II) complexes [Ni(dpb)(carboxylate)] (Hdpb = 1,3-di(2-pyridyl)benzene) for Negishi-type CC cross coupling

Discussions

• A great review! doi.org/10.1021/acs.... [bsky, 2 points, 0 comments]

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