Nesprin-1α contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope

2004/12/15 by Geneviève C. Paré, Genevieve C. Pare, Juliet L. Easlick +5 · 31 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Nuclear Structure and Function #Ion channel regulation and function #Cardiomyopathy and Myosin Studies

paper · doi:10.1016/j.yexcr.2004.10.009

Citations

• Nesprin‐1α self‐associates and binds directly to emerin and lamin A in vitro

Cited by

• Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes
• AKAP6β – A Conductor in the Orchestra of Pathological Cardiomyocyte Gene Transcription
• Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions
• Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells
• Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice
• Nesprin-1 and -2 are involved in the pathogenesis of Emery–Dreifuss muscular dystrophy and are critical for nuclear envelope integrity
• The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice. [europepmc]
• Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. [europepmc]
• mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. [europepmc]
• The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. [europepmc]
• AKAPs: the architectural underpinnings of local cAMP signaling. [europepmc]
• The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing. [europepmc]
• Role of phospholipase Cε in physiological phosphoinositide signaling networks. [europepmc]
• Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy. [europepmc]
• Creating order from chaos: cellular regulation by kinase anchoring. [europepmc]
• Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes. [europepmc]
• Mechanics of the nucleus. [europepmc]
• Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains. [europepmc]
• Nesprins: tissue-specific expression of epsilon and other short isoforms. [europepmc]
• Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy. [europepmc]
• mAKAP-a master scaffold for cardiac remodeling. [europepmc]
• Accessorizing and anchoring the LINC complex for multifunctionality. [europepmc]
• Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins. [europepmc]
• Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. [europepmc]
• Function of Adenylyl Cyclase in Heart: the AKAP Connection. [europepmc]
• Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System. [europepmc]
• Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment. [europepmc]
• Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure. [europepmc]
• AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9. [europepmc]
• Subcellular Organization of the cAMP Signaling Pathway. [europepmc]
• Understanding the molecular basis of cardiomyopathy. [europepmc]