Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes

2012/12/21 by Jinliang Li, Maximilian A.X. Vargas, Michael S. Kapiloff +2 · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Signaling Pathways in Disease #Peptidase Inhibition and Analysis #Histone Deacetylase Inhibitors Research

paper · doi:10.1016/j.yexcr.2012.12.016

Citations

• The mAKAPβ scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin
• Nesprin-1α contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope

Cited by

• AKAP6β – A Conductor in the Orchestra of Pathological Cardiomyocyte Gene Transcription
• Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions
• The scaffold protein muscle A-kinase anchoring protein β orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. [europepmc]
• mAKAP-a master scaffold for cardiac remodeling. [europepmc]
• Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins. [europepmc]
• Genome-wide epigenetic analysis of MEF2A and MEF2C transcription factors in mouse cortical neurons. [europepmc]
• Calcineurin signaling in the heart: The importance of time and place. [europepmc]
• MEF2 signaling and human diseases. [europepmc]
• Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes. [europepmc]
• Calcineurin-AKAP interactions: therapeutic targeting of a pleiotropic enzyme with a little help from its friends. [europepmc]
• Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. [europepmc]
• mAKAPβ signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling. [europepmc]
• Cardiac function modulation depends on the A-kinase anchoring protein complex. [europepmc]
• FGF22 promotes generation of ribbon synapses through downregulating MEF2D. [europepmc]
• The calmodulin redox sensor controls myogenesis. [europepmc]
• Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction. [europepmc]
• Calcineurin in the heart: New horizons for an old friend. [europepmc]
• Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy. [europepmc]
• A perinuclear calcium compartment regulates cardiac myocyte hypertrophy. [europepmc]
• Protections of transcription factor BACH2 and natural product myricetin against pathological cardiac hypertrophy and dysfunction. [europepmc]
• Phosphorylation, compartmentalization, and cardiac function. [europepmc]
• Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks. [europepmc]
• Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration. [europepmc]
• Regulation of cardiac function by cAMP nanodomains. [europepmc]
• A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling. [europepmc]
• Therapeutic Inhibition of LincRNA-p21 Protects Against Cardiac Hypertrophy. [europepmc]
• Nanodomain cAMP signaling in cardiac pathophysiology: potential for developing targeted therapeutic interventions. [europepmc]