AKAP6β – A Conductor in the Orchestra of Pathological Cardiomyocyte Gene Transcription

2026/07/01 by Sinan Aydin, Michael S. Kapiloff, Kimberly L. Dodge-Kafka +1
Biochemistry, Genetics and Molecular Biology · Medicine · #Congenital heart defects research #Cardiomyopathy and Myosin Studies #Cardiac electrophysiology and arrhythmias

paper · doi:10.1016/j.molpha.2026.100145

Citations

• Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes
• The mAKAPβ scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin
• The architecture of microtubular network and Golgi orientation in osteoclasts—major differences between avian and mammalian species
• Nesprin‐1α self‐associates and binds directly to emerin and lamin A in vitro
• Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy
• Nesprin-1α contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope
• Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies
• RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome
• Roles and regulation of protein phosphatase 2A (PP2A) in the heart
• β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573
• A perinuclear calcium compartment regulates cardiac myocyte hypertrophy