A Brief Measure for Assessing Generalized Anxiety Disorder
2006/05/22 by Robert L. Spitzer, Kurt Kroenke, Janet B. W. Williams +2 · 32,069 citations
Arts and Humanities · Medicine · Psychology · #Anxiety #Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes #Child and Adolescent Psychosocial and Emotional Development #Clinical psychology #Construct validity #Convergent validity #Criterion validity #Generalized anxiety disorder #Historical Art and Architecture Studies #Historical Studies of Medieval Iberia #Medical diagnosis #Medicine #Medieval Architecture and Archaeology #Mental Health Research Topics #Mental health #Psychiatry #Psychology #Psychometrics
paper · doi:10.1001/archinte.166.10.1092
published in Archives of Internal Medicine 166(10), 1092 (American Medical Association)
openalex publication_date 2006/05/22 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/05
Abstract
BACKGROUND: Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. METHODS: A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. RESULTS: A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. CONCLUSION: The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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- Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey
- The double-edged perfectionist parenting: an examination of its impact on adolescent internet gaming addiction (IGA)
- Daily patterns of substance use among young adults who vape nicotine and cannabis: Latent class analysis of smartphone-based daily diary data
- Effect of Adding Milk to a Micronutrient-Fortified High-Energy Biscuit School Feeding Programme in Yemen: A Cluster-Randomized Controlled Trial
- “How is your thesis going?”–Ph.D. students’ perspectives on mental health and stress in academia
- Braving the dark: mental health challenges and academic performance of Ukrainian university students during the war
- A multisystem, dimensional interplay of assets versus adversities: Revised benevolent childhood experiences (BCEs) in the context of childhood maltreatment, threat, and deprivation
- Sleep and Activity Patterns as Transdiagnostic Behavioral Biomarkers in Psychiatry: Initial Insights from the DeeP-DD study
- The role of sunlight in sleep regulation: analysis of morning, evening and late exposure
- Digital CBT for insomnia and emotion regulation in the workplace: a randomised waitlist-controlled trial
- Impact of theatre interventions on mental health: a systematic literature review and meta-analysis
- Subtypes of suicidal ideation among university students – An ecological momentary assessment study
- The Effect of Noncongregate Emergency Shelters on Occupant Well-Being, Chico, California, 2023
- Nature-based outdoor activities for mental and physical health: Systematic review and meta-analysis
- Evaluating Dose Response of Cognitive Behavioural Therapy Using Outpatient Electronic Medical Record Data: An Observational Study: Évaluer la relation dose-réponse de la thérapie cognitivo-comportementale au moyen des données des DME des patients externes : Une étude d’observation
- Exploring cross-cultural effectiveness of internet-based depression treatment (IBAT-D) with peer-to-peer support vs. without across WEIRD and non-WEIRD samples: a research protocol for a randomized controlled trial
- Mental health and school adaptation among immigrant, refugee, and non-immigrant adolescents
- Predictors of quality of life in OCD: Machine-derived features beyond expert consensus
- Maternal childhood adversity as an upstream vulnerability for prenatal alcohol use and maternal mental health
- Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome
- Anxiety, depression, trauma-related, and sleep disorders among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis
- A study of resting-state EEG biomarkers for depression recognition
- Toward estimating personal well-being using voice
- Individual-level Anxiety Detection and Prediction from Longitudinal YouTube and Google Search Engagement Logs
- Autistic women report high levels of pain, pain-related anxiety, and pain interference
- Hardship and Hope: The Relationship Between Unconditional Prenatal and Infant Cash Transfers, Economic Stability, and Maternal Mental Health and Well-Being
- Economic Insecurities and Mental Health Among Low-Income Pregnant People in the Central Valley Region of California
- Anxiety and Cognition in Multiple Sclerosis: A Narrative Review
- Adverse childhood experiences partially mediate sexual minority disparities in depression, anxiety, and suicidality in a population-based study
- Back on track: Feasibility and efficacy randomized trial of a two-week online self-guided intervention for cannabis use reduction
- National Worry and the Psychological Value of Social Spending
- Creating a Robot Coach for Mindfulness and Wellbeing: A Longitudinal Study
- Increased Depression and Anxiety Among Men and Transgender Women Receiving Care at a Sexual Health Clinic in New York City During COVID-19
- Non‐discontinuation of antiseizure medication in seizure‐free patients with epilepsy: Reasons and predictors among neurologists and patients
- Gendered patterns of mental health in STEM higher education: A cluster and regression approach
- Optimization of Internet-Delivered Cognitive Behavioral Therapy for Canadian Leaders Within Public Safety: Qualitative Study
- Evaluating the necessity of booster sessions in relapse prevention for depression: a longitudinal study
- Opening Up Library Systems
- Remote mental healthcare before and during the COVID-19 Pandemic: A retrospective observational study using routine outcome measurements
- Guided, internet based, cognitive behavioural therapy for post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID)
- Active Components in Internet-Based Cognitive-Behavioral Therapy for Social Anxiety Disorder: A Randomized Full Factorial Trial
- Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update
- Fighting OCD together: An experimental study of the effectiveness and acceptability of seeking and receiving emotional support for OCD
- Is repeated mistake-making an effective treatment strategy for perfectionism? Findings from a randomized controlled trial
- Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia
- What happens after menopause? (WHAM): A prospective controlled study of depression and anxiety up to 12 months after premenopausal risk-reducing bilateral salpingo-oophorectomy
- Is exercise a viable therapy for anxiety? Systematic review of recent literature and critical analysis
- Persistent cognitive symptoms in mild COVID-19 infection: a retrospective cohort study
- Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study
- The use of patient reported outcome measures in routine cancer clinical care: results from a freedom of information request
- Deterioration of sleep and mental health in individuals with insomnia during South Africa’s COVID-19 lockdown
- Identification of drug repurposing candidates for the treatment of anxiety: A genetic approach
- Reducing medical cannabis use risk among Veterans: A descriptive study
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
- Somatic Symptom Disorder After Mild Traumatic Brain Injury
- Attention to affective pictures and emotional arousal between naturally cycling women, oral contraceptive users and men: Evidence from eye tracking and pupillometry
- Social network alcohol use is associated with individual‐level alcohol use among Black sexually minoritized men and gender‐expansive people: Findings from the Neighborhoods and Networks (N2) cohort study
- Stress and episodic future thinking: Effects on temporal window and alcohol demand
- Emotional responses to prosocial messages increase willingness to self-isolate during the COVID-19 pandemic
- Associations between masturbation frequency, anxiety, and sleep disturbances during the COVID-19 era
- A Longitudinal Study of Financial Difficulties and Mental Health in a National Sample of British Undergraduate Students
- Conceptualizing Mental Health Through Bhutanese Refugee Lens: Findings from a Mixed Methods Study
- Mental Health, Physical Health, and Cultural Characteristics Among American Indians/Alaska Natives Seeking Substance Use Treatment in an Urban Setting: A Descriptive Study
- Effect of COVID-19 pandemic on mental health among Bangladeshi healthcare professionals: A cross-sectional study
- E-Cigarette use (Vaping) is associated with Illicit drug use, Mental Health Problems, and Impulsivity in University Students
- Anxiety and depression status in patients with idiopathic pulmonary fibrosis and outcomes of nintedanib treatment: an observational study
- AWARENESS: Development of a cognitive–behavioral intervention to address intersectional minority stress for sexual minority men living with HIV who use substances.
- Anxiety and depression symptoms and their association with discrimination and a lack of social support among first- and second-generation immigrant adolescents
- Successful application of pulsed electromagnetic fields in a patient with post-COVID-19 fatigue: a case report
- Critical Insights about Robots for Mental Wellbeing
- The LifeTrack Project: Baseline cohort characteristics and psychosocial factors associated with duration of suicidal ideation and prior suicide attempt
- User journey method: a case study for improving digital intervention use measurement
- Explaining a collective false alarm: Context and cognition in the Oxford Street crowd flight incident
- Trajectories of mental health status during the early phase pandemic in China: A longitudinal study on adolescents living in the community with confirmed cases
- Loneliness mediates the association between insecure attachment and mental health among university students
- Daily longitudinal self-monitoring of mood variability in bipolar disorder and borderline personality disorder
- Impacts of socio-cultural environment and lifestyle factors on the psychological health of university students in Bangladesh: A longitudinal study
- The real-world burden of adults with major depressive disorder with moderate or severe insomnia symptoms in the United States
- Relative effects of treatment history and family environment on attention functioning in pediatric cancer survivors
- Assessing the role of race/ethnicity in the relationships among spiritual struggles, health, and well-being.
- Domestic violence survivors’ housing stability, safety, and well-being over time: Examining the role of domestic violence housing first, social support, and material hardship.
- Health behavior and anxiety changes during the COVID-19 pandemic among students, faculty, and staff at a US university
- Period poverty and mental health among students attending a US university
- Students under lockdown: Comparisons of students’ social networks and mental health before and during the COVID-19 crisis in Switzerland
- Music listening as emotion regulation: Associations with other emotion regulation strategies and symptoms of depression and anxiety
- Dietary changes and anxiety during the coronavirus pandemic: a multinational survey
- Large-scale digital phenotyping: Identifying depression and anxiety indicators in a general UK population with over 10,000 participants
- An Explainable Anomaly Detection Framework for Monitoring Depression and Anxiety Using Consumer Wearable Devices
- A pilot randomised controlled trial of acceptance and commitment therapy for medication decision‐making and quality of life in women with breast cancer: The ACTION trial
- Effectiveness of Combined Cognitive Processing Therapy with Stellate Ganglion Block: An Open-Label Randomized Wait-List Clinical Trial
- Finding freedom in Appalachia: evaluating a mental health intervention in West Virginia
- Real-Time Stress Monitoring, Detection, and Management in College Students: A Wearable Technology and Machine-Learning Approach
- Posttraumatic Stress Disorder and Somatic Complaints in a Deployed Cohort of Georgian Military Personnel: Mediating Effect of Depression and Anxiety
- Greater Social Isolation and Social Constraints Prior to Hematopoietic Stem Cell Transplant Are Associated with Greater Anxiety and Depressive Symptoms
- Accuracy of screening for symptoms of anxiety and depression among patients with osteoarthritis in private physiotherapy practices
- Manic symptoms in schizophrenia spectrum disorders
- Health-related quality of life is impaired in people with autoimmune hepatitis: Results of a multicentre cross-sectional study within the European Reference Network
- Prevalence and socio-demographic correlates of probable depression and anxiety symptoms in Mozambique: A secondary data analysis
- Chronic pelvic pain among transgender men and gender diverse adults assigned female at birth
- Identifying impaired mental health in patients with type 2 diabetes: a cross-sectional study in general practice
- Psilocybin-assisted massed cognitive processing therapy for chronic posttraumatic stress disorder: Protocol for an open-label pilot feasibility trial
- The Mental and Physical Health Profiles of Older Adults Who Endorse Elevated Autistic Traits
- Risk factors associated with mental illness in hospital discharged patients infected with COVID-19 in Wuhan, China
- A Longitudinal Comprehensive Biospecimen and Clinical Data Repository for Cancer Early Detection: The InAdvance Study
- The role of trait mindfulness in moderating climate distress during wildfire season
- Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort
- Coping with Type 2 diabetes: Commonly used strategies associated with mental wellbeing and treatment engagement
- Differentiating Procrastinators from Each Other: A Cluster Analysis
- Towards automated symptoms assessment in mental health
- Addressing the critical need for long-term mental health data during the COVID-19 pandemic: Changes in mental health from April to September 2020
- Rates of, and factors associated with, common mental disorders in homeworking UK Government response employees’ during COVID-19: a cross-sectional survey and secondary data analysis
- Reciprocal developmental pathways between future-related thinking and symptoms of adolescent depression and anxiety: A systematic review and meta-analysis of longitudinal studies.
- What matters for adolescent suicidality: Depressive symptoms or fixed mindsets? Examination of cross‐sectional and longitudinal associations between fixed mindsets and suicidal ideation
- Substance use in youth at risk for psychosis
- Change in child mental health during the Ukraine war: evidence from a large sample of parents
- The levonorgestrel-releasing intrauterine device is related to early emotional reactivity: An ERP study
- Fostering compliance with physical distancing by interactive feedback in the context of the COVID-19 pandemic: A web-based randomized controlled trial
- Opioid cessation and chronic pain: perspectives of former opioid users
- Parent-child mental health in Ukraine in relation to war trauma and drone attacks
- Food insecurity is associated with eating disorders independent of depression and anxiety: Findings from the 2020–2021 Healthy Minds Study
- Social Support, Depression and Anxiety in Cancer Patient‐Relative Dyads in Early Survivorship: An Actor‐Partner Interdependence Modeling Approach
- Mental Disorder Symptoms among Public Safety Personnel in Canada
- Post-intensive care syndrome: a state-of-the-art review
- The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a systematic review
- Gender Differences in Attitudes Towards Drug Use Among South Korean College Students: A Latent Class Analysis
- PRECiS (Patient Reported Evaluation of Cognitive State): psychometric evaluation of a new patient reported outcome measure of the impact of stroke
- Mental Health Outcomes in Transgender and Nonbinary Youths Receiving Gender-Affirming Care
- Ensuring that the Improving Access to Psychological Therapies (IAPT) programme does what it says on the tin
- A DSM-5-Based Online Mental Health Referral Inventory: A Large-Scale Validation Study
- What works best? A meta‐analysis exploring the efficacy of different types of cognitive behaviour therapy for generalized anxiety disorder
- Associations between intimate partner violence profiles and mental health among low-income, urban pregnant adolescents
- Mental health disorders and utilization of mental healthcare services in United Nations personnel
- An Intervention to Enhance Goals-of-Care Communication Between Heart Failure Patients and Heart Failure Providers
- The first 30 months of the MindSpot Clinic: Evaluation of a national e-mental health service against project objectives
- Psychological Adaptation to Alteration of Body Image among Stoma Patients: A Descriptive Study
- Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic
- Pilot trial of a parenting and self-care intervention for HIV-positive mothers: the IMAGE program
- Recent Advances in the Understanding and Treatment of Anxiety Disorders
- Internet Treatment for Generalized Anxiety Disorder: A Randomized Controlled Trial Comparing Clinician vs. Technician Assistance
- Cognitive behavioural therapy for tinnitus
- Storm Clouds and Silver Linings: Day-to-Day Life in COVID-19 Lockdown and Emotional Health in Adolescent Girls
- Classroom Mindfulness Education Effects on Meditation Frequency, Stress, and Self-Regulation
- The clinical characterization of the adult patient with depression aimed at personalization of management
- Single-session gamified virtual reality exposure therapy for spider phobia vs. traditional exposure therapy: study protocol for a randomized controlled non-inferiority trial
- The association between food insecurity and mental health during the COVID-19 pandemic
- Subjective Birth Experience and Person-Centred Care in Obstetrics: Study Protocol of the Prospective Mixed-Methods Research Project RESPECT
- Deep Learning Characterizes Depression and Suicidal Ideation from Eye Movements
- “I’m So Tired”: Fatigue as a Persistent Physical Symptom among Working People Experiencing Exhaustion Disorder
- Inquiry into the correlation between burnout and depression.
- An exploratory structural equation modeling bi-factor analytic approach to uncovering what burnout, depression, and anxiety scales measure.
- Using Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial
- Optimal Question Selection from a Large Question Bank for Clinical Field Recovery in Conversational Psychiatric Intake
- MIND: Empowering Mental Health Clinicians with Multimodal Data Insights through a Narrative Dashboard
- Responsible Evaluation of AI for Mental Health
- Association between adverse experiences during Hurricane María and mental and emotional distress among adults in Puerto Rico
- Moral injury, mental health and behavioural health outcomes: A systematic review of the literature
- Affective empathy predicts self-isolation behaviour acceptance during coronavirus risk exposure
- Infidelity’s aftermath: Appraisals, mental health, and health-compromising behaviors following a partner’s infidelity
- A Community-based Cross-sectional Study of a Tiered Mental Health Support Model for Frontline Workers in Andhra Pradesh during the COVID-19 Pandemic
- Measuring Mental Health Variables in Computational Research: Toward Validated, Dimensional, and Transdiagnostic Approaches
- Beyond the battlefield: Interpersonal predictors of women's mental health during extended partner deployment
- Creative arts therapies for the mental health of emerging adults: A systematic review
- Military and nonmilitary stressors associated with mental health outcomes among female military spouses
- ClassPass Memberships to Improve Well-Being Among Psychiatry Residents: A Pilot Randomized Controlled Trial
- Group Psychosocial Interventions Following Acquired Brain Injury: A Systematic Review and Meta-analysis of Group Process and Outcomes
- Interest in anime and manga: relationship with (mental) health, social disconnectedness, social joy and subjective well-being
- Mental health impacts of anti-trans stigma on transgender people in Australia: a mixed-methods study
- Development, Reliability, and Initial Validation of the Fear of Institutional Betrayal Questionnaire
- On the Measurement of Climate Change Anxiety: French Validation of the Climate Anxiety Scale
- Does anxiety moderate the effectiveness of mirtazapine in patients with treatment-resistant depression? A secondary analysis of the MIR trial
- Plausible Patients, Impossible Populations: Auditing Epidemiological Fidelity in Large Language Model Mental Health Simulations
- Anxiety and Aggression Among College Students With High‐Risk Adverse Childhood Experiences: The Role of Bullying Perpetration
- Trauma, immigration, and sexual health among Latina women: Implications for maternal–child well‐being and reproductive justice
- Psychological Impact of Analytical Treatment Interruption on Young Women Enrolled in an HIV Cure-Related Clinical Trial in Durban, South Africa
- The hidden price of food allergy: Understanding the social and financial burdens on families
- Distress screening and management for adolescents and young adults: 2022 NCI community oncology program landscape assessment
- Mental Health and Social Connectedness Across the Adult Lifespan in the Context of the COVID-19 Pandemic
- Cognitive-Behavioral Treatment of Tomophobia (Fear of Medical Procedures) Using an Innovative, Virtual-Reality-Augmented Approach: A Case Study in a Patient With Breast Cancer
- Network analysis of depression and anxiety symptom relationships in a psychiatric sample. [europepmc]
- Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial. [europepmc]
- The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. [europepmc]
- Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial. [europepmc]
- Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. [europepmc]
- The Global Prevalence of Anxiety Among Medical Students: A Meta-Analysis. [europepmc]
- Mental health problems and social media exposure during COVID-19 outbreak. [europepmc]
- Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey. [europepmc]
- Prevalence and socio-demographic correlates of psychological health problems in Chinese adolescents during the outbreak of COVID-19. [europepmc]
- Mental health consequences during the initial stage of the 2020 Coronavirus pandemic (COVID-19) in Spain. [europepmc]
- Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. [europepmc]
- Depression and Anxiety in Hong Kong during COVID-19. [europepmc]
- Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: Clinical implications for U.S. young adult mental health. [europepmc]
- The effect of age, gender, income, work, and physical activity on mental health during coronavirus disease (COVID-19) lockdown in Austria. [europepmc]
- Students under lockdown: Comparisons of students' social networks and mental health before and during the COVID-19 crisis in Switzerland. [europepmc]
- COVID-19 Pandemic and Lockdown Measures Impact on Mental Health Among the General Population in Italy. [europepmc]
- The enemy who sealed the world: effects quarantine due to the COVID-19 on sleep quality, anxiety, and psychological distress in the Italian population. [europepmc]
- Stress and parenting during the global COVID-19 pandemic. [europepmc]
- Loneliness in the UK during the COVID-19 pandemic: Cross-sectional results from the COVID-19 Psychological Wellbeing Study. [europepmc]
- The prevalence of depression, anxiety, and sleep disturbances in COVID-19 patients: a meta-analysis. [europepmc]
- Mental health and well-being during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental Health & Wellbeing study. [europepmc]
- Trajectories of anxiety and depressive symptoms during enforced isolation due to COVID-19 in England: a longitudinal observational study. [europepmc]
- Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge. [europepmc]
- Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study. [europepmc]
- Distinguishing features of long COVID identified through immune profiling. [europepmc]
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