2025/03/14 by Barksdale, Alex C., Niebel, Frauke H., Chacon-Caldera, Jorge +7
#2-D magnetic particle imaging #FFL imaging #Hypercapnia #Non-Human Primate #cerebral blood volume #functional Brain imaging #functional neuroimaging #time-series
paper · doi:10.18416/ijmpi.2025.2503029
MPI offers a promising alternative to fMRI for detecting changes in cerebral blood volume (CBV) during brain activation, potentially enabling single-patient functional brain mapping. We assess our human-scale MPI brain scanner by imaging anesthetized non-human primates, achieving continuous imaging with 5 s temporal and 7 mm spatial resolution. We successfully detect CBV modulations during alternating cycles of hypercapnia and normocapnia, achieving a CNR of up to 7.9 following activations in the brain region.