2026/06/24 by Anna Padányi, Balázs Knakker, Evelin Kiefer +2 · 1 voice
Medicine · Neuroscience · #Intraoperative Neuromonitoring and Anesthetic Effects #Spatial Neglect and Hemispheric Dysfunction #Transcranial Magnetic Stimulation Studies
paper · doi:10.1016/j.isci.2026.116384
openalex publication_date 2026/06/24 · openalex created_date 2026/06/25 · openalex updated_date 2026/07/25
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique widely employed in basic and clinical research. Non-human primates (NHPs) represent translationally valuable models due to their close anatomical and functional similarity to humans. However, significant technical challenges remain in implementing human-like TMS protocols in awake NHPs. Here, we developed a non-invasive head- and arm-fixation apparatus that enables reliable stimulation and electromyography recordings in awake NHPs without surgical intervention and validated the apparatus with two TMS protocols in rhesus macaques. First, we implemented an adaptive motor threshold (MT) determination method developed recently for humans, which converged successfully to valid MTs as defined by the International Federation of Clinical Neurophysiology. Second, we measured a robust short-interval intracortical inhibition effect for the first time in awake NHPs. Successful implementation of human TMS protocols in awake NHPs provides proof-of-concept validation of our apparatus, paving the way to bidirectionally translatable, clinically relevant neuromodulation protocols.