2025/10/24 by Pisarović, Uma, Ochi, Taichi, Samarska, Iryna +6
#FOS: Physical sciences #Medical Physics (physics.med-ph) #Optics (physics.optics)
paper · doi:10.48550/arxiv.2510.21260
In recent years, light-sheet fluorescence microscopy (LSFM) has emerged as a powerful tool for visualizing and analyzing cancer tissue samples, including patient-derived specimens, organoids, biopsies, and murine models. In this work, we highlight the current applications of deep tissue LSFM in oncology and illustrate its use across a variety of human cancer tissues, including - but not limited to - prostate and breast. Here, we discuss that the potential integration of advanced LSFM technologies into clinical workflows to enable high-throughput, three-dimensional imaging of intact cancer specimens. This approach holds significant potential to enhance diagnostic precision and provide novel insights into tumour architecture and morphology.