The PI3K/AKT Pathway as a Target for Cancer Treatment

2015/10/16 by Ingrid A. Mayer, Carlos L. Arteaga · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemical and Molecular Research #Biology #Cancer #Cancer research #Carcinogenesis #Cell biology #Cell cycle #Chronic Lymphocytic Leukemia Research #Internal medicine #Medicine #Oncogene #PI3K/AKT/mTOR pathway #PI3K/AKT/mTOR signaling in cancer #PTEN #Protein kinase B #Signal transduction #Suppressor

paper · pdf · doi:10.1146/annurev-med-062913-051343

openalex publication_date 2015/10/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

Anticancer targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene and/or loss of a tumor suppressor. Genes in the phosphoinositide 3-kinase (PI3K)/AKT pathway are the most frequently altered in human cancers. Aberrant activation of this pathway, as a result of these somatic alterations, is associated with cellular transformation, tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK are currently in clinical trials, alone or in combination, in both solid tumors and hematologic malignancies. These drugs are the focus of this review.

Citations

• Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

Cited by

• The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation
• Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
• PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
• Targeting PI3K/Akt signal transduction for cancer therapy
• Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance
• Cell motility in cancer invasion and metastasis: insights from simple model organisms
• Molecular insights into cancer drug resistance from a proteomics perspective
• Therapeutic target discovery using Boolean network attractors: improvements of kali

Related

• Targeting PI3K/Akt signal transduction for cancer therapy
• PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeutics
• PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
• Acquired resistance to molecularly targeted therapies for cancer
• PIK3CB promotes oesophageal cancer proliferation through the PI3K/AKT/mTOR signalling axis