Tim B. Bigdeli
- Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
2015/10/01 by Bjarni J. Vilhjálmsson, Bjarni J. Vilhjálmsson, Jian Yang +452 · 61 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Advanced Causal Inference Techniques #Allele #Artificial intelligence #Bioinformatics and Genomic Networks #Biology #Computer science #Disequilibrium #Genetic Associations and Epidemiology #Genetics #Haplotype #Linkage disequilibrium #Mathematics #Medicine #Pattern recognition (psychology) #Polygenic risk score #Pruning #Sample (material) #Sample size determination #Single-nucleotide polymorphism #Statistics #Thresholding
- Mapping genomic loci implicates genes and synaptic biology in schizophrenia
2022/04/08 by Vassily Trubetskoy, Antonio F. Pardiñas, Ting Qi +97 · 67 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomic variations and chromosomal abnormalities #Genomics and Rare Diseases
- Biological insights from 108 schizophrenia-associated genetic loci
2014/07/01 by Stephan Ripke, B M Neale, Kai-How Farh +97 · 18 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Diabetes and associated disorders #Genetic Associations and Epidemiology #Tryptophan and brain disorders
- Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
2021/05/17 by Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell +97 · 31 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Bipolar Disorder and Treatment #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders
- Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
2018/11/19 by Raymond K. Walters, Renato Polimanti, Emma C. Johnson +188 · 7 citations
Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals
- Rare coding variants in ten genes confer substantial risk for schizophrenia
2022/04/08 by Tarjinder Singh, Timothy Poterba, David Curtis +97 · 1 voice · 8 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomic variations and chromosomal abnormalities #Genomics and Rare Diseases
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
2018/04/26 by eQTLGen, Naomi R. Wray, 23andMe +237 · 4 citations
Biochemistry, Genetics and Molecular Biology · #BRCA gene mutations in cancer #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders
- Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies
2025/01/14 by Mark J. Adams, F Streit, Xiangrui Meng +97 · 2 voices · 6 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · #Genetic Associations and Epidemiology #Mental Health Research Topics #Tryptophan and brain disorders
- Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
2017/09/22 by Wouter J. Peyrot, Sandra Van der Auwera, Pamela A. F. Madden +92 · 1 citation
Biochemistry, Genetics and Molecular Biology · Psychology · #Genetic Associations and Epidemiology #Cognitive Abilities and Testing #Child Abuse and Trauma
- Sparse whole-genome sequencing identifies two loci for major depressive disorder
2015/07/14 by Na Cai, Tim B. Bigdeli, Warren Kretzschmar +108 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Endoplasmic Reticulum Stress and Disease #Plant Gene Expression Analysis #Sirtuins and Resveratrol in Medicine