Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

2018/11/19 by Raymond K. Walters, Renato Polimanti, Emma C. Johnson +188 · 5 citations
Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals

paper · doi:10.1038/s41593-018-0275-1

openalex created_date 2018/03/29 · openalex publication_date 2018/11/19 · crossref created 2018/11/19 · crossref issued 2018/11/26 · crossref published 2018/11/26 · crossref published-online 2018/11/26 · crossref published-print 2018/12/01 · crossref deposited 2026/04/04 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/04

Citations

• Estimating Missing Heritability for Disease from Genome-wide Association Studies
• The Genotype-Tissue Expression (GTEx) project
• Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies
• Genetic Basis of Complex Genetic Disease: The Contribution of Disease Heterogeneity to Missing Heritability
• Bias reduction of maximum likelihood estimates
• Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children
• Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
• Collider scope: when selection bias can substantially influence observed associations
• KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
• Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
• Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population

Cited by

• Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
• Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review
• Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
• Molecular genetics of cocaine use disorders in humans
• Genetic variants associated with longitudinal changes in brain structure across the lifespan
• Alcoholism [wikipedia]