Jean‐Laurent Casanova

1. Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee
   2020/01/01 by Stuart G. Tangye, Waleed Al–Herz, Aziz Bousfiha +14 · 16 citations
   Immunology and Microbiology · Medicine · #Cystic Fibrosis Research Advances #Immunodeficiency and Autoimmune Disorders #Tumors and Oncological Cases
2. Parsing the Interferon Transcriptional Network and Its Disease Associations
   2016/01/01 by Sara Mostafavi, Hideyuki Yoshida, Devapregasan Moodley +26 · 7 citations
   Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · Medicine · #interferon and immune responses #RNA and protein synthesis mechanisms #Cytokine Signaling Pathways and Interactions
3. Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine
   2021/02/05 by Paul Bastard, Eleftherios Michailidis, Hans-Heinrich Hoffmann +42 · 1 voice · 12 citations
   Immunology and Microbiology · Medicine · #Immune Cell Function and Interaction #Mosquito-borne diseases and control #interferon and immune responses
4. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients
   2023/05/27 by Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini +59 · 1 voice · 11 citations
   Immunology and Microbiology · Medicine · #Complement system in diseases #Mosquito-borne diseases and control #Viral Infections and Vectors
5. Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
   2022/10/06 by Aurélien Sokal, Paul Bastard, Pascal Chappert +64 · 25 citations
   Medicine · Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #SARS-CoV-2 and COVID-19 Research #Immune Cell Function and Interaction #Diabetes and associated disorders
6. Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification
   2020/01/01 by Aziz Bousfiha, Leïla Jeddane, Capucine Pïcard +16 · 7 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Blood disorders and treatments #Immunodeficiency and Autoimmune Disorders #Tumors and Oncological Cases
7. Severe infectious diseases of childhood as monogenic inborn errors of immunity
   2015/11/30 by Jean‐Laurent Casanova · 1 voice · 4 citations
   Immunology and Microbiology · Medicine · #Blood groups and transfusion #Immunodeficiency and Autoimmune Disorders #Parvovirus B19 Infection Studies
8. Lethal Infectious Diseases as Inborn Errors of Immunity: Toward a Synthesis of the Germ and Genetic Theories
   2020/04/14 by Jean‐Laurent Casanova, Laurent Abel · 1 voice · 5 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Blood disorders and treatments #Immunodeficiency and Autoimmune Disorders #Parvovirus B19 Infection Studies
9. Human autoantibodies underlying infectious diseases
   2022/03/23 by Anne Puel, Paul Bastard, Jacinta Bustamante +1 · 1 voice · 4 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Diabetes and associated disorders #Immunodeficiency and Autoimmune Disorders #T-cell and B-cell Immunology
10. Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis
    2025/10/28 by Adrian Gervais, Astrid Marchal, Soraya Boucherit +33 · 1 voice · 8 citations
    Medicine · #Liver Diseases and Immunity #Hepatitis Viruses Studies and Epidemiology #Hepatitis C virus research
11. A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity
    2024/12/16 by Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd +91 · 3 voices · 1 citation
    Immunology and Microbiology · #interferon and immune responses #Immune Cell Function and Interaction #Immunodeficiency and Autoimmune Disorders
12. Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza
    2025/11/18 by Qian Zhang, Taylor Conrad, Marcela Moncada‐Vélez +15 · 1 voice · 8 citations
    Immunology and Microbiology · Medicine · #interferon and immune responses #Influenza Virus Research Studies #Respiratory viral infections research
13. Human genetic basis of interindividual variability in the course of infection
    2015/11/30 by Jean‐Laurent Casanova · 1 voice · 1 citation
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Immunodeficiency and Autoimmune Disorders #RNA and protein synthesis mechanisms #RNA modifications and cancer
14. Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance
    2021/01/06 by Franck Rapaport, Bertrand Boisson, Anne Gregor +13 · 1 voice · 1 citation
    Biochemistry, Genetics and Molecular Biology · Medicine · #Genetics and Neurodevelopmental Disorders #Genomics and Rare Diseases #Neurogenetic and Muscular Disorders Research
15. The Microbe, the Infection Enigma, and the Host
    2024/07/10 by Jean‐Laurent Casanova, Laurent Abel · 1 voice · 3 citations
    Environmental Science · Medicine · #Bacteriophages and microbial interactions #Viral gastroenteritis research and epidemiology #Zoonotic diseases and public health
16. The ouroboros of autoimmunity
    2024/05/01 by Jean-Laurent Casanova, Jean‐Laurent Casanova, Jessica Peel +6 · 1 voice · 2 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Blood disorders and treatments #Immune Response and Inflammation #Immunodeficiency and Autoimmune Disorders
17. Human immunity
    2025/02/14 by Jean‐Laurent Casanova · 1 voice · 2 citations
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Diabetes and associated disorders #Immune Cell Function and Interaction #Immune responses and vaccinations
18. Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
    2015/08/24 by Alexandra Y. Kreins, Michael J. Ciancanelli, Satoshi Okada +51 · 1 voice · 1 citation
    Immunology and Microbiology · #Immunodeficiency and Autoimmune Disorders #Immune Cell Function and Interaction #T-cell and B-cell Immunology
19. Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)
    2026/07/16 by Conor Gruber, Meredith Ramba, Bineeta Debnath +38 · 1 voice
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Immunodeficiency and Autoimmune Disorders #Inflammasome and immune disorders #interferon and immune responses