Evan D. Kharasch
- Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites
2006/05/01 by Bojan Lalovic, Evan D. Kharasch, C HOFFER +3 · 5 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Pain Management and Opioid Use #Pharmacogenetics and Drug Metabolism
- Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance
2016/10/20 by Lesley K. Rao, Alicia M. Flaker, Christina Friedel +1 · 4 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Treatment of Major Depression #Pharmacogenetics and Drug Metabolism #Drug-Induced Hepatotoxicity and Protection
- Lack of effect of cimetidine on acetaminophen disposition in humans
1989/11/01 by John T. Slattery, John T Slattery, Teresa I McRorie +8 · 5 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Acetaminophen #Biochemistry #Biology #Chemistry #Cimetidine #Clinical pharmacology #Drug Transport and Resistance Mechanisms #Drug-Induced Hepatotoxicity and Protection #Enzyme #Glucuronidation #Glucuronide #Malaria Research and Control #Medicine #Metabolite #Microsome #Pharmacokinetics #Pharmacology #Urine #Volunteer
- Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy
2021/01/02 by Kristine R. Crews, Andrew A. Monte, Rachel Huddart +18 · 4 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Diet and metabolism studies #Pharmaceutical studies and practices #Pharmacogenetics and Drug Metabolism
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype
2011/12/28 by Kristine R. Crews, Andrea Gaedigk, Henry M. Dunnenberger +5 · 4 citations
Pharmacology, Toxicology and Pharmaceutics · Medicine · #Pharmacogenetics and Drug Metabolism #Cancer Treatment and Pharmacology #Pain Management and Opioid Use
- Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches
2018/12/27 by Pan‐Fen Wang, Alicia Neiner, Thomas R. Lane +3 · 2 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · Computer Science · #Treatment of Major Depression #Pharmacogenetics and Drug Metabolism #Computational Drug Discovery Methods
- Common Polymorphisms ofCYP2B6Influence Stereoselective Bupropion Disposition
2018/05/14 by Evan D. Kharasch, Amanda Crafford · 9 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Bupropion #CYP2B6 #CYP2C19 #CYP3A4 #Chemistry #Cytochrome P450 #Enzyme #Hydroxylation #Medicine #Metabolism #Pharmacogenetics and Drug Metabolism #Pharmacology #Pharmacology and Obesity Treatment #Poisoning and overdose treatments #Smoking cessation