Christopher J. Schofield
- X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes
1993/07/01 by Clayton R. Randall, Yan Zang, Anne E. True +7 · 17 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Active site #Antibiotic Resistance in Bacteria #Carboxylate #Chemistry #Crystallography #Cysteine #Enzyme #Ferrous #Ligand (biochemistry) #Metal complexes synthesis and properties #Metal-Catalyzed Oxygenation Mechanisms #Organic chemistry #Stereochemistry #Substrate (aquarium)
- 2-Oxoglutarate-Dependent Oxygenases
2018/03/01 by Md. Saiful Islam, Thomas M. Leissing, T.M. Leissing +3 · 12 citations
Chemistry · Biochemistry, Genetics and Molecular Biology · #Metal-Catalyzed Oxygenation Mechanisms #Microbial metabolism and enzyme function #Biochemical Acid Research Studies
- Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine
2023/02/09 by Lennart Brewitz, Leo Dumjahn, Yilin Zhao +13 · 1 voice · 5 citations
Chemistry · Medicine · Computer Science · #Click Chemistry and Applications #SARS-CoV-2 and COVID-19 Research #Computational Drug Discovery Methods
- Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification
2023/10/12 by Lennart Brewitz, H. T. Henry Chan, Petra Lukacik +4 · 1 voice · 2 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Peptidase Inhibition and Analysis #Ubiquitin and proteasome pathways #interferon and immune responses
- Unusual catalytic strategy by non-heme Fe( ii )/2-oxoglutarate-dependent aspartyl hydroxylase AspH
2024/01/01 by Anandhu Krishnan, Sodiq O. Waheed, Ann Varghese +3 · 1 voice · 1 citation
Chemistry · Energy · #CO2 Reduction Techniques and Catalysts #Metal-Catalyzed Oxygenation Mechanisms #Metalloenzymes and iron-sulfur proteins
- The enzymes of β-lactam biosynthesis
2013/01/01 by Refaat B. Hamed, J. Ruben Gomez-Castellanos, Luc Henry +3 · 1 citation
- Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles
2015/12/15 by Anne Makena, Azer Özad Düzgün, Jürgen Brem +7 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotic Resistance in Bacteria #Tuberculosis Research and Epidemiology #Pneumocystis jirovecii pneumonia detection and treatment
- Proteins of the penicillin biosynthesis pathway
1997/12/01 by Christopher J Schofield, Christopher J. Schofield, Jack E Baldwin +11 · 1 citation
Biochemistry, Genetics and Molecular Biology · Computer Science · Medicine · #Computational Drug Discovery Methods #Microbial Natural Products and Biosynthesis #bioluminescence and chemiluminescence research
- PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase
2009/10/19 by Christoph Loenarz, Wei Ge, Mathew L. Coleman +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Epigenetics and DNA Methylation #RNA modifications and cancer #Folate and B Vitamins Research #Demethylase #Biology #Exon #Genetics #Histone #Missense mutation #Gene #Mutation #Histone H3 #Molecular biology #Biochemistry
- Targeting Protein–Protein Interactions in the HIF System
2016/03/21 by Sarah E. Wilkins, Martine I. Abboud, Rebecca L. Hancock +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer, Hypoxia, and Metabolism #Adipose Tissue and Metabolism #High Altitude and Hypoxia
- Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010/08/22 by Christoph Loenarz, Christopher J. Schofield · 1 citation
Biochemistry, Genetics and Molecular Biology · #Cancer, Hypoxia, and Metabolism #Epigenetics and DNA Methylation #RNA modifications and cancer