Preparation of 2,3-Disubstituted 5-Bromo-1H-pyrrolo[2,3-b]pyridine Framework by Fischer Cyclization

2015/07/15 by Roman Alekseyev, R. S. Alekseyev, Sabina Amirova +3
Chemistry · #Synthesis and Reactivity of Heterocycles #Synthesis and Biological Evaluation #Catalytic C–H Functionalization Methods

paper · doi:10.1055/s-0034-1381040

Abstract

A simple synthesis of some hard-to-reach heterocycles containing 2,3-disubstituted 5-bromo-1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridine framework by Fisсher indole cyclization in polyphosphoric acid has been developed. A particularly valuable feature of this synthetic route is the possibility to build a 5-bromo-7-azaindole scaffold with alkyl or aryl substituents at positions 2 and 3 from available starting materials.

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