SYNTHESIS OF NEW 5-BROMO-1H-INDOLE-2,3-DIONE DERIVATIVES BY 1,3-DIPOLAR CYCLOADDITION

2020/09/13 by Kharbach, Y., Youssef, Kandri Rodi, Elmsellem, H. +6
#1 #3-dipolar cycloaddition #5-bromoisatin #dipolarophile #heterocyclic.

paper · doi:10.48317/imist.prsm/morjchem-v5i1.7960

Abstract

To contribute to the development of the chemistry of 5-bromo-isatin, we have synthesized new heterocyclic systems, using alkylation reactions under conditions of phase transfer catalysis to be then subjected to cycloaddition reactions dipolar involving 1,3-dipoles. The structures of the various products obtained were determined by 1H NMR, 13C NMR spectroscopy.

Related

• Synthesis and reactivity of new heterocyclic systems derived from 5-chloro-1H-indole-2,3-dione
• 1,3‐Dipolar Cycloadditions. Past and Future
• Preparation of 2,3-Disubstituted 5-Bromo-1H-pyrrolo[2,3-b]pyridine Framework by Fischer Cyclization
• Synthesis of 3,3-di(1-(2-phenylbenzyl)indole-3-yl)-5-bromoindoline-2-one
• Two-Step Route to Indoles and Analogues from Haloarenes: A Variation on the Fischer Indole Synthesis