Cascade Nucleophilic Addition–Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties

2023/06/01 by Gurupada Hazra, Sayantan Kundu, Rambabu Dandela +1
Chemistry · #Cyclization and Aryne Chemistry #Chemical synthesis and alkaloids #Synthesis and Biological Evaluation

paper · doi:10.1021/acs.joc.3c00462

Abstract

A facile synthetic approach to 6 H -pyrrolo[3,2,1- de ]acridines has been developed by using cascade N -nucleophilic addition–cyclic Michael addition process of arynes and indoles substituted with Michael acceptors under metal-free conditions. Additionally, photophysical studies of a few of the newly synthesized pyrroloacridine compounds indicated good fluorescence emission properties.

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