Stereoselective Acetate Aldol Reactions from Metal Enolates

2011/05/10 by Pedro Romea, Fèlix Urpí, Fèlix Urpı́ +3
Chemistry · #Asymmetric Synthesis and Catalysis #Synthetic Organic Chemistry Methods #Asymmetric Hydrogenation and Catalysis

paper · doi:10.1055/s-0030-1260040

Abstract

This review deals with metal enolate-mediated stereoselective acetate aldol reactions. It summarizes recent advances on aldol additions of unsubstituted metal enolates from chiral auxiliaries, stoichiometric and catalytic Lewis acids, or acting in substrate- controlled reactions, which provide stereocontrolled aldol transformations that allow the efficient synthesis of structurally complex natural products.

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