Ni-Catalyzed Highly Chemo-, Regio-, and Enantioselective Decarboxylative Aldol Reaction of β,γ-Unsaturated α-Ketoesters with β-Ketoacids

2015/03/18 by Ai-Jia Wei, Ai‐Jia Wei, Jing Nie +3 · 2 citations
Chemistry · #Asymmetric Synthesis and Catalysis #Asymmetric Hydrogenation and Catalysis #Synthetic Organic Chemistry Methods

paper · doi:10.1021/jo502741z

Abstract

A novel Ni-catalyzed decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a convenient approach to access enantioenriched chiral tertiary alcohols.

Cited by

• Enantioselective Synthesis of Chromanones Bearing an α,α-Disubstituted α-Amino Acid Moiety via Decarboxylative Michael Reaction. [europepmc]
• Further developments of β,γ -unsaturated α -ketoesters as versatile synthons in asymmetric catalysis. [europepmc]

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