(Chloromethyl)magnesium Chloride–Lithium Chloride: A Chemoselective Reagent for the Synthesis of Functionalized Aromatic Chlorohydrins

2015/03/04 by Giuliano Clososki, Giuliano C. Clososki, Rodolfo Hideki Vicente Nishimura +5 · 24 citations
Chemistry · #Asymmetric Synthesis and Catalysis #Carbenoid #Catalysis #Chemistry #Chloride #Coordination Chemistry and Organometallics #Cyclopropane Reaction Mechanisms #Inorganic chemistry #Lithium (medication) #Lithium chloride #Magnesium #Organic chemistry #Reactivity (psychology) #Reagent #Rhodium

paper · open access · doi:10.1055/s-0034-1380288

published in Synthesis 47(10), 1455-1460 (Thieme Medical Publishers (Germany))

openalex publication_date 2015/03/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

The reactivity of (chloromethyl)magnesium chloride–lithium chloride (ClCH₂MgCl·LiCl), a mixed lithium–magnesium carbenoid, in reactions with aromatic aldehydes bearing various functional groups is reported. The reagent is highly chemoselective, permitting the synthesis of a range of ring-functionalized aromatic chlorohydrins in high yields.

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