2017/10/08 by Niankai Fu, Gregory S. Sauer, Song Lin · 1 citation
Chemistry · #Radical Photochemical Reactions #Oxidative Organic Chemistry Reactions #Vanadium and Halogenation Chemistry
paper · doi:10.1021/jacs.7b09388
openalex publication_date 2017/10/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
We report a Mn-catalyzed electrochemical dichlorination of alkenes with MgCl 2 as the chlorine source. This method provides operationally simple, sustainable, and efficient access to a variety of vicinally dichlorinated compounds. In particular, alkenes with oxidatively labile functional groups, such as alcohols, aldehydes, sulfides, and amines, were transformed into the desired vicinal dichlorides with high chemoselectivity. Mechanistic data are consistent with metal-mediated Cl atom transfer as the predominant pathway enabling dual C–Cl bond formation and contradict an alternative pathway involving electrochemical evolution of chlorine gas followed by Cl 2 -mediated electrophilic dichlorination.