Achieving red-light anticancer photodynamic therapy under hypoxia using Ir( iii )–COUPY conjugates

2025/01/01 by Enrique Ortega, Anna Rovira, Pezhman Ashoo +14 · 4 voices · 16 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · Mathematics · Medicine · #Cancer research #Cancer, Hypoxia, and Metabolism #Chemistry #Conjugate #Hypoxia (environmental) #Mathematics #Medicine #Nanoplatforms for cancer theranostics #Organic chemistry #Oxygen #Pharmacology #Photodynamic Therapy Research Studies #Photodynamic therapy

paper · pdf · doi:10.1039/d4qi03369h

published in Inorganic Chemistry Frontiers 12(9), 3367-3383 (Royal Society of Chemistry)

openalex publication_date 2025/01/01 · openalex created_date 2025/03/05 · openalex updated_date 2026/08/06

Abstract

Conjugation of COUPY dyes to cyclometalated Ir( iii ) complexes is a strategy at the frontier of the development of red-light-activated photosensitizers capable of operating under challenging hypoxic conditions, showing the promise of anticancer PDT.

Citations

• A guided tour into subcellular colocalization analysis in light microscopy
• A Threshold Selection Method from Gray-Level Histograms
• Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Cited by

• Metal–coumarin derivatives as promising photosensitizers: unlocking their cancer phototherapy potential
• Hypoxia active cyclometalated Ir( iii ) Nile red triplet photosensitisers
• Novel Heteroleptic Iridium(III) Complexes Containing COUBPY Ligands for Effective Photoinduction of Ferroptosis for Cancer Therapy. [europepmc]
• NIR pH-Responsive PEGylated PLGA Nanoparticles as Effective Phototoxic Agents in Resistant PDAC Cells. [europepmc]
• π-Extended Ru-COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light. [europepmc]
• Novel 2-(2'-Benzothiazolyl)-benzimidazole-Based Iridium(III) Photocatalysts Exhibit Antiproliferative Effects in 2D and 3D Cancer Cells to Bypass Hypoxia-Induced Resistance. [europepmc]

Discussions

• Happy to see our paper in print! We developed an iridium-coumarin platform that selectively induces oxidative cell death upon red light exposure, even in low-oxygen conditions! 🧪 Congrats to the team [bsky, 36 points, 1 comments]
• Nice to see our recent article on the Front cover- now published in Inorganic Chemistry Frontiers. doi.org/10.1039/D4QI.... Great collaboration with @MarchanLab_UB. [bsky, 12 points, 0 comments]
• 📢Issue 09 of Inorganic Chemistry Frontiers is online! 👇Check out the outside front cover and the research behind the cover art——Achieving red-light #anticancer #photodynamic therapy under hypoxia u [bsky, 1 points, 0 comments]
• Glad to see our last collaboration on Ir metal complexes for anticancer photodynamic therapy published in Inorg. Chem. Front.!!! @inorgchemfront.rsc.org doi.org/10.1039/D4QI... [bsky, 1 points, 0 comments]

Related

• Hypoxia active cyclometalated Ir( iii ) Nile red triplet photosensitisers
• Synthesis and evaluation of anticancer activity in vitro and in vivo of photoactivated iridium(III) complex
• Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
• π-Extended Ru–COUBPY Photosensitizers for In Vivo Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light
• Encapsulation of a Cyclometalated Iridium(III) Photosensitizer into Nanosized Micelles for Oncosis-Inducing Photodynamic Therapy