Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
2021/09/28 by Thanh Chung Pham, Van-Nghia Nguyen, Nguyễn Văn Nghĩa +3 · 1,745 citations
Chemistry · Engineering · Materials Science · Medicine · Psychology · #Cancer #Cancer therapy #Chemistry #Internal medicine #Luminescence and Fluorescent Materials #Materials science #Medicine #Nanoplatforms for cancer theranostics #Nanotechnology #Organic chemistry #Photochemistry #Photodynamic Therapy Research Studies #Photodynamic therapy #Photosensitizer #Psychology #Rational design #Surprise
paper · doi:10.1021/acs.chemrev.1c00381
published in Chemical Reviews 121(21), 13454-13619 (American Chemical Society)
openalex publication_date 2021/09/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Abstract
This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.
Citations
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