Cysteine-selective [ 188 Re]Re( v ) radiolabelling of a Nanobody® for targeted radionuclide therapy using a “chelate-then-click” approach

2025/01/01 by Diana R. Melis, Charlotte Segers, Jasmien Wellens +5 · 1 voice · 2 citations
Medicine · #Radiopharmaceutical Chemistry and Applications #Medical Imaging Techniques and Applications #Medical Imaging and Pathology Studies

paper · pdf · doi:10.1039/d4sc07743a

Abstract

Re, although further optimisation or alternative radiolabelling strategies to enhance the molar activity are necessary to improve pharmacokinetics.

Cited by

• Chelator Optimization and Therapeutic Potential of 188 Re-FAPI for FAP-Targeted Radionuclide Therapy. [europepmc]
• Side-by-Side Comparison of Different Thiol Bioconjugation Strategies for the Chemoselective Radiolabeling of Human Serum Albumin with Zirconium-89. [europepmc]

Discussions

• Congrats @dianamelis.bsky.social for her article in @chemicalscience.rsc.org. We describe the 1st use of bioorthogonal click chemistry with 188Re for radiolabelling of an anti-c-Met VHH Nanobody®. Gre [bsky, 45 points, 1 comments]

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