Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted 99m Tc, 64 Cu and 188 Re radiotracers

2025/01/01 by Rachel E. Nuttall, Ingebjørg N. Hungnes, Truc T. Pham +13 · 1 voice
Medicine · #Lung Cancer Treatments and Mutations #Medical Imaging Techniques and Applications #Radiopharmaceutical Chemistry and Applications

paper · pdf · doi:10.1039/d5sc02110c

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Two new, versatile bis(phosphino)maleic anhydride platforms enable facile preparation of diphosphine bioconjugates that can be simply radiolabelled with 99m Tc for SPECT imaging, 64 Cu for PET imaging and 188 Re for systemic radiotherapy.

Discussions

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