Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms

2024/12/09 by Bruno Hagenbuch, Bruno Stieger, Kaspar P. Locher · 37 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Amino Acid Enzymes and Metabolism #Analytical Chemistry and Chromatography #Biochemistry #Biology #Chemistry #Drug Transport and Resistance Mechanisms #Medicine #Pharmacology #Toxicology

paper · open access · doi:10.1016/j.pharmr.2024.100023

published in Pharmacological Reviews 77(2), 100023 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2024/12/09 · openalex created_date 2024/12/10 · openalex updated_date 2026/08/01

Citations

• Protein kinase C affects the internalization and recycling of organic anion transporting polypeptide 1B1
• Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2
• Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides
• Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer
• Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in Humans
• Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes
• Ueber Diffusion

Cited by

• Role of organic anion transporting polypeptides in pancreatic statin disposition and islet cell function in mice
• Predicting inhibitors of OATP1B1 via heterogeneous OATP-ligand interaction graph neural network (HOLIgraph). [europepmc]
• Ex vivo perfusion model of mouse liver and its application to analyze the effects of OCT1 deficiency. [europepmc]
• Hepatic organic anion transporting polypeptides (OATPs) as MRI reporter proteins. [europepmc]
• Evaluation of in Vitro Cytotoxicity and Induction Potential of Açaí ( Euterpe oleracea) Extracts in Human Hepatocytes. [europepmc]
• Post-translational regulation of organic anion transporting polypeptide 1B3 transport function by lysine acetylation and lysine deacetylase 6 inhibition. [europepmc]
• Hepatocyte SLCO4C1 is a cAMP uptake transporter for inhibiting lipogenesis and a therapeutic target for MASLD. [europepmc]
• Selectivity of OATs and OATPs for Endogenous Metabolites and Signaling Molecules In Vivo . [europepmc]
• [Fe-EOB-tCDTA] generates strong contrast in the blood but not in the liver, despite inhibiting cellular [Gd-EOB-DTPA] 2- uptake and partial liver excretion. [europepmc]
• Crosstalk along the gut-liver axis modulates glutathione and cadmium-induced hepatotoxicity. [europepmc]
• Deorphanisation and functional characterisation of OATP5A1 as transport protein for amino acids and vitamins. [europepmc]