Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

2018/02/12 by Jamie E. Moscovitz, Amit S. Kalgutkar, Kelly Nulick +4 · 71 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Aryl hydrocarbon receptor #Biochemistry #Biology #CYP2B6 #CYP3A4 #Cell biology #Constitutive androstane receptor #Cytochrome P450 #Drug #Drug Transport and Resistance Mechanisms #Drug metabolism #Gene #Gene expression #Genetics #Hormonal Regulation and Hypertension #Metabolism #Nuclear receptor #Pharmacogenetics and Drug Metabolism #Pharmacology #Pregnane X receptor #Regulation of gene expression #Transcription factor #Transcriptional regulation

paper · pdf · doi:10.1124/jpet.117.247296

published in Journal of Pharmacology and Experimental Therapeutics 365(2), 262-271 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2018/02/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26

Citations

• FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

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