Essential Role of Calmodulin in RyR Inhibition by Dantrolene

2015/04/29 by Ye Win Oo, Nieves Gómez‐Hurtado, Nieves Gomez-Hurtado +8 · 26 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Environmental Science · #Ion channel regulation and function #Cardiac electrophysiology and arrhythmias #Marine Toxins and Detection Methods

paper · pdf · doi:10.1124/mol.115.097691

Cited by

• Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator
• Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease. [europepmc]
• CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. [europepmc]
• Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases. [europepmc]
• Reduced threshold for store overload-induced Ca 2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease. [europepmc]
• Organelle membrane derived patches: reshaping classical methods for new targets. [europepmc]
• The structural basis of ryanodine receptor ion channel function. [europepmc]
• EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. [europepmc]
• Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines. [europepmc]
• Role of STIM1/ORAI1-mediated store-operated Ca 2+ entry in skeletal muscle physiology and disease. [europepmc]
• Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. [europepmc]
• Genome-Wide Association Study Identifies Genomic Loci Affecting Filet Firmness and Protein Content in Rainbow Trout. [europepmc]
• Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia. [europepmc]
• Diurnal properties of voltage-gated Ca 2+ currents in suprachiasmatic nucleus and roles in action potential firing. [europepmc]
• Evidence of functional ryanodine receptors in rat mesenteric collecting lymphatic vessels. [europepmc]
• Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models. [europepmc]
• RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca 2+ assays. [europepmc]
• Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation. [europepmc]
• Calsequestrin: a well-known but curious protein in skeletal muscle. [europepmc]
• CaMKII-dependent ryanodine receptor phosphorylation mediates sepsis-induced cardiomyocyte apoptosis. [europepmc]
• Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. [europepmc]
• Emerging Antiarrhythmic Drugs for Atrial Fibrillation. [europepmc]
• Structural Insight Into Ryanodine Receptor Channelopathies. [europepmc]
• Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research. [europepmc]
• Molecular Aspects Implicated in Dantrolene Selectivity with Respect to Ryanodine Receptor Isoforms. [europepmc]
• Clustering properties of the cardiac ryanodine receptor in health and heart failure. [europepmc]