Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator

2025/10/31 by Tri Q., Tri Q. Do, Daniel J. Blackwell +6 · 2 voices
Biochemistry, Genetics and Molecular Biology · Medicine · #Calcium signaling and nucleotide metabolism #Cardiac electrophysiology and arrhythmias #Ion channel regulation and function

paper · pdf · doi:10.1016/j.molpha.2025.100086

openalex created_date 2025/10/31 · openalex publication_date 2025/10/31 · crossref created 2025/10/31 · crossref issued 2025/12/01 · crossref published 2025/12/01 · crossref published-print 2025/12/01 · crossref deposited 2026/03/19 · crossref indexed 2026/03/19 · openalex updated_date 2026/08/01

Citations

• Essential Role of Calmodulin in RyR Inhibition by Dantrolene
• A drug and ATP binding site in type 1 ryanodine receptor

Discussions

• Tri Do, PharmD, is the Molecular Pharmacology Highlighted Trainee Author for December 2025. His research focuses on how drugs interact with proteins in the heart that control electrical activity, spec [bsky, 0 points, 0 comments]
• Tri Do, PharmD, is the Molecular Pharmacology Highlighted Trainee Author for December 2025. His research focuses on how drugs interact with proteins in the heart that control electrical activity, spec [bsky, 0 points, 0 comments]