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Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology

1999/10/14 by Niels Fertig, N. Fertig, Fertig, N. +12
Biochemistry, Genetics and Molecular Biology · Neuroscience · Physics and Astronomy · #FOS: Biological sciences #FOS: Physical sciences #Ion channel regulation and function #Neuroscience and Neural Engineering #Photoreceptor and optogenetics research #Quantitative Biology (q-bio) #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft #q-bio

paper · pdf · doi:10.48550/arxiv.cond-mat/9910217

arxiv created 1999/10/14 · openalex publication_date 1999/10/14 · arxiv updated 2009/11/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based devices 'on-chip' promises novel types of experiments on single ion channels.

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