Viral Fitness and Antigenic Determinants of Porcine Parvovirus at the Amino Acid Level of the Capsid Protein

2021/11/10 by André Felipe Streck, Cláudio Wageck Canal, Uwe Truyen · 6 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Veterinary · #Amino acid #Animal Virus Infections Studies #Animal health and immunology #Antigenic variation #Capsid #Epitope #Minute virus of mice #Parvoviridae #Parvovirus #Porcine parvovirus #Viral replication #Virus #Virus-based gene therapy research

paper · doi:10.1128/jvi.01198-21

openalex publication_date 2021/11/10 · openalex created_date 2021/11/22 · openalex updated_date 2026/07/28

Abstract

Porcine parvovirus is one of the most important causes of reproductive failure in swine. Recently, despite the continuous use of vaccines, "new" strains emerged, leading to the hypothesis that the emergence of new amino acid substitutions could be a viral adaptation to the immune response against the commercial vaccines. Our results indicate the amino acid substitutions observed in the 27a-like strains can modify viral fitness and antigenicity. However, an absolute immune escape was not evident.

Cited by

• Allele-Specific Dual PCRs to Identify Members of the 27a Cluster of PPV. [europepmc]
• Isolation, characterization, and phylogenetic analysis of two new porcine parvovirus 1 isolates from Northern China. [europepmc]
• Molecular Survey on Porcine Parvoviruses (PPV1-7) and Their Association with Major Pathogens in Reproductive Failure Outbreaks in Northern Italy. [europepmc]
• The Identification of Dual T-Cell and B-Cell Epitopes Within Viral Proteins Utilizing a Comprehensive Peptide Array Approach. [europepmc]
• Epidemiological analysis and detection of a 27a-like porcine parvovirus strain with pathogenicity in pregnant sows in Japan. [europepmc]
• Porcine Parvovirus virus-like particle vaccine induces long-term humoral immunity by recruiting T follicular helper and germinal center B cell responses. [europepmc]

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