Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest

2015/10/15 by Yizhong Ren, Chufang Li, Liqiang Feng +10 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #Endoplasmic Reticulum Stress and Disease #Calcium signaling and nucleotide metabolism

paper · pdf · doi:10.1128/jvi.00576-15

Abstract

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosomes with lysosomes, which might be a key mechanism for arresting autophagy.

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• Sarco/Endoplasmic Reticulum Ca ²⁺ -Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells

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