2021/03/10 by Jiaojiao Peng, Yeqian Ran, Haojun Xie +3
Medicine · Biochemistry, Genetics and Molecular Biology · #Autophagy in Disease and Therapy #Endoplasmic Reticulum Stress and Disease #Heme Oxygenase-1 and Carbon Monoxide
paper · doi:10.1128/jvi.00217-21
IAV is a major cause of infectious respiratory diseases, characterized by a marked respiratory tract inflammatory response that causes morbidity and mortality in seasonal epidemics, or pandemic outbreaks. SERCA is a critical component in maintaining cellular calcium levels, and is positively correlated with autophagic flux. Here, we discovered that SERCA is suppressed in IAV-infected human lung cells and influenza A virus induces blocking of autophagic flux, inflammatory response and mitochondrial dysfunction by inhibiting SERCA. We posit that the pharmacological activation of SERCA can be a powerful intervention strategy to prevent autophagy arrest, inflammatory response, and mitochondrial dysfunction in IAV-infected cells. Therefore, SERCA activity modulation could be a potential therapeutic strategy for managing clinical symptoms of severe influenza disease.