Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

2005/05/26 by Liuquan Chang, Liuquan (Lucy) Chang, Deanna Shepherd +6 · 6 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Microencapsulation and Drying Processes #Protein purification and stability #Proteins in Food Systems

paper · pdf · doi:10.1002/jps.20364

Citations

• Solid‐state chemical stability of proteins and peptides

Cited by

• Correlations between Molecular Mobility and Chemical Stability During Storage of Amorphous Pharmaceuticals
• Formulation Design of Dry Powders for Inhalation
• Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. correlation of protein–sugar interaction with native structure preservation
• El milenario de Cataluña
• Dielectric spectroscopy of the low-losses sugar lyophilises: IV. Comparative study of four disaccharides at different moisture contents and temperatures
• Engineering nasally delivered IgM antibodies for respiratory viral infections
• Thermodynamic Basis of Sugar-Dependent Polymer Stabilization: Informing Biologic Formulation Design