Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

2005/02/01 by Francisco J.M. Mojica, Francisco J. M. Mojica, Chc)sar D�ez-Villase�or +2 · 48 citations
Biochemistry, Genetics and Molecular Biology · Environmental Science · Agricultural and Biological Sciences · #CRISPR and Genetic Engineering #Bacteriophages and microbial interactions #Insect symbiosis and bacterial influences

paper · doi:10.1007/s00239-004-0046-3

Cited by

• In defense of funding foundational plant science
• Evolutionary Genomics of Defense Systems in Archaea and Bacteria
• Live-cell imaging reveals the trade-off between target search flexibility and efficiency for Cas9 and Cas12a
• Inverted repeats in coronavirus SARS-CoV-2 genome and implications in evolution
• Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications
• Tool Choice drastically Impacts CRISPR Spacer-Protospacer Detection
• Cas9-based enrichment for targeted long-read metabarcoding
• CRISPR-based diagnostics
• Cas9-based enrichment for targeted long-read metabarcoding
• A comprehensive review of genomic-scale genetic engineering as a strategy to improve bacterial productivity
• And… cut! – how conformational regulation of CRISPR-Cas effectors directs nuclease activity
• Evo-Inspired Engineering of Radical Phenotypes and Emergent Traits
• CRISPR-Cas spacer acquisition is a rare event in human gut microbiome
• A 300 bp non-coding repeat sequence has co-evolved with the ced-2/CRKII-set-23/SETMAR genes of nematodes
• Treating genetic blood disorders in the era of CRISPR-mediated genome editing
• Data Mining by Pluralistic Approach on CRISPR Gene Editing in Plants
• Turbo‐charging crop improvement: harnessing multiplex editing for polygenic trait engineering and beyond
• CRISPR-Cas13a system: A novel tool for molecular diagnostics
• Live-cell imaging reveals the trade-off between target search flexibility and efficiency for Cas9 and Cas12a
• A CRISPRi Gene Regulation System for Bifidobacteria
• Critical role of Cas9 aggregation on in vitro DNA cleavage
• Rational design of unrestricted pRN1 derivatives and their application in the construction of a dual plasmid vector system for Saccharolobus islandicus
• Bacteria exploit viral dormancy to establish CRISPR-Cas immunity
• Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. [europepmc]
• A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. [europepmc]
• Evolutionary conservation of sequence and secondary structures in CRISPR repeats. [europepmc]
• The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats. [europepmc]
• CRISPR recognition tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats. [europepmc]
• Small CRISPR RNAs guide antiviral defense in prokaryotes. [europepmc]
• RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. [europepmc]
• Self versus non-self discrimination during CRISPR RNA-directed immunity. [europepmc]
• CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. [europepmc]
• The phage-host arms race: shaping the evolution of microbes. [europepmc]
• CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. [europepmc]
• Evolution and classification of the CRISPR-Cas systems. [europepmc]
• Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems. [europepmc]
• Structures of the RNA-guided surveillance complex from a bacterial immune system. [europepmc]
• CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity. [europepmc]
• The rise of regulatory RNA. [europepmc]
• Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. [europepmc]
• Development and applications of CRISPR-Cas9 for genome engineering. [europepmc]
• Unravelling the structural and mechanistic basis of CRISPR-Cas systems. [europepmc]
• Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity. [europepmc]
• Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems. [europepmc]
• Inhibition of CRISPR-Cas9 with Bacteriophage Proteins. [europepmc]
• The promise of organ and tissue preservation to transform medicine. [europepmc]
• Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications. [europepmc]
• CRISPR/Cas9 therapeutics: progress and prospects. [europepmc]